so i have heard that certain strains have more anti convulsant qualities than others. I know the answer lies in the cannabinoid profile, i believe its the CBN that is NOT recommended for folks who suffer from seizures. Anyone heard anymore to this effect? or otherwise?

ALSO...

Does anyone know what particular strains might work best to quell my recent nervous seizure fits? Cuz im shakin like an earthquake every 10 minutes and I dont like the prescription the ER doc gave me. Thank you!!

Miss Lane

[oRANGEgumby]

I too have been wondering what others take on this is. I find that for me a kush with a citrus/orange taste and properly cured seem to work the best for me....

[eclectic]

Indica dominant strains seem to help the most
Vaporizing seems to be better aswell in my expirience with an epilectic
But the most important thing is that the herb is grown organically, cured properly, and not moldy! Including the mildew that can usually only be seen with a magnifying glass/microscope.
Mold is one of the causes of epilepsy believe it or not!!!
Dosage is very important aswell so dose slowly to get the right effect.

I was at a Co-op today and i saw a nice helpful little chart on the wall that had a nice little break down of each Cannabinoid. This chart corrected my previous assumption and stated that CBN was the cannabinoid know to be most active as an Anti-convulsant. There were no references on the chart so i couldnt find out where they got the info, but im gonna try to find out! That is all! Peace, Bless!

[Capt. Zigzag]

My roommate, a quad, get the most relief from his tremors, using strong kushes.

-

Lana, I don't think there is a good answer other than anecdotal info.

I do a lot of cannabis research and have in record 9 studies about epilepsy and cannabis medicine. None of them have the same results....
Some were done hastily without good controls and some from prominent researchers contradict each other...

I think till there is lots more studies done on cannabis and epilepsy, you may have to rely on the best tool we have so far: Bio-assay* and recomendations from patients with this disorder.

I hope you find a strain that gives you more relief!

Stay Well,
LG

* Bio-assay: Try it to see if it works for you.

[MediKaliNumb]

A good kush can definatly help but depending on the pheno it can hurt you too.Just stick with a good strain that keeps you nice and relaxed.

[HappaGuy]

Anti-convulsant cannabinoid profiles?
so i have heard that certain strains have more anti convulsant qualities than others. I know the answer lies in the cannabinoid profile, i believe its the CBN that is NOT recommended for folks who suffer from seizures. Anyone heard anymore to this effect? or otherwise?

ALSO...

Does anyone know what particular strains might work best to quell my recent nervous seizure fits? Cuz im shakin like an earthquake every 10 minutes and I dont like the prescription the ER doc gave me. Thank you!!

Miss Lane

Re what strains: Go for the indicas with the powerful body buzz. Grandaddy Purple, Urkle, those really do it for me.

Miss Lane, I urge you to ASAP get a primary care physician and a referral to a neurologist (I don't know why the ER did not) and get EEGS done and do trials of pharmaceutical anti-seizure meds.

To have seizures every ten minutes is close to "status epilepticus" or perpetual chronic seizure, the most severe form of epilepsy, if I am not mistaken. I presume you are petit mal or else your life might well have ended by now without treatment.

If I am not mistaken "cannabinoid profile" refers to the relative quantities of each of the many the different molecules that make us happy, popularly referred to as THC, which however is really only one of them. These molecules each have different volatility (they boil at different specific temperatures within the range of 340-420 degrees Fahrenheit.

I believe I get more relief from seizures from some of the heavier, less volatile cannabinoid molecules, such as CBN. (Actually I had thought CBN either refers to cannabinoids as a class but it may refer to a particular molecule now that you mention it.) This would seem to agree with the chart you saw on that club's wall, to which you refer in a later post. I believe the cannabinoid profile of the indica strains are richer in these heavier molecules.

Whatever. I find I can get very good relief, very physical relief, from some of the cruder, heavier, less volatile cannabinoids that are usually left over by vaporizers. I have a friend who vaporizes huge quantities of good herb and gives me the tailings. I heat these on a fry pan at 400 degrees F and suck the vapors out of a thick glass blender jar upended on the fry pan. (Please search for my posts on the "EZ-Vapor method".) I find this stuff very effective for calming my misbehaving nerves especially before bed. It is best to have regular herb too of course, but the richness of CBN's in vapor tailings seem to really scratch that particular neurological itch.

I find that cannabis is necessary, but not sufficient, to handle my seizures. I know of my seizures (from EEGs but) primarily through the severe insomnia they seem to cause. I take Klonapin before bed, and a gram and a half of Trileptal (1500Mgs) every day, and smoke/vaporize a LOT of cannabis, and I am mostly ok if I avoid contact with people. This is the necessary and sufficient set of conditions to allow me to function more or less.

You sound like you have a MUCH more severe case, and like you haven't got a neurologist on it. I'm concerned.

You might want to follow these basics until you have a better handle on your particular case.:
I AVOID THESE THINGS LIKE POISON:
(a) Alcohol
(b) Adrenalin (anger and fear and stress, anything that sets these off)
(c) Insomnia (leads to more seizures to more insomnia, in my case anyway.)

I wish you very good luck. Please PM me if you need some private emotional support.

CAVEAT: You are not me while all the foregoing presumes that your case may have similarities to mine. However I have complex partial seizures which allow no direct awareness of having them, nor can anyone tell me who is not trained to spot them, and I am (otherwise happily) single. So it's hard to tell how it goes with me. But I have learned to trust what my body tells me.

It sounds like you have a different class of seizure, -petit mal epilepsy. But if I'm not mistaken the neurological basics are pretty much the same, differing more in degree and pattern of onset more than kind. So I hope this may be of help to you.

[HappaGuy]

Originally Posted by HappaGuy

Re what strains: Go for the indicas with the powerful body buzz. Grandaddy Purple, Urkle, those really do it for me.

Miss Lane, I urge you to ASAP get a primary care physician and a referral to a neurologist (I don't know why the ER did not) and get EEGS done and do trials of pharmaceutical anti-seizure meds.

To have seizures every ten minutes is close to "status epilepticus" or perpetual chronic seizure, the most severe form of epilepsy, if I am not mistaken. I presume you are petit mal or else your life might well have ended by now without treatment.

I did some checking on 'status epilepticus' at Wikipedia. I hope you find the following helpful.

Status epilepticus (SE) refers to a life threatening condition in which the brain is in a state of persistent seizure. Definitions vary, but traditionally it is defined as one continuous seizure or recurrent seizures without regaining consciousness between seizures for greater than 30 minutes. Many doctors, however, believe that 5 minutes is sufficient to damage neurons and that seizures are unlikely to self-terminate by that time.

In known epileptics, this condition is associated with poor compliance (adherence to medication regimen), alcohol withdrawal, and metabolic disturbances. As a primary presentation it normally indicates a tumour or abscess.

It can also be induced by nerve agents such as soman.[1]

SOURCE: Status epilepticus - Wikipedia, the free encyclopedia

----

Epilepsia partialis continua is a rare type of brain disorder in which a patient experiences recurrent motor epileptic seizures that are focal (hands and face), and recur every few seconds or minutes for extended periods (days or years).

[edit] Presentation

During these seizures, there is repetitive focal myoclonus or Jacksonian march. After a seizure has subsided, Todd's phenomenon may be observed, which includes transient unilateral weakness.

SOURCE: Epilepsia partialis continua - Wikipedia, the free encyclopedia

Complex Partial Status Epilepticus (CPSE) is one of the non-convulsive forms of Status epilepticus, a rare form of epilepsy defined by its recurrent nature. CPSE is characterized by seizures involving long-lasting stupor, staring and unresponsiveness.[1] Sometimes this is accompanied by motor automatisms, such as eye twitching.[2]

SOURCE: Complex partial status epilepticus - Wikipedia, the free encyclopedia

[Absynthe]

Sorry, don't mean to crash the Epilepsy area, but I suffer from Epilepsy's little sister: Chronic Migraines, with light sensitivity (slow flashing lights can make me nauseaus, and space for a few seconds).

I find the hybrid works well for my Migraines. Kush seems to work for my overall pain.

[stinky]

I suffer from seizures due to neck and back problems. Sometimes I feel like someone has a live wire stuck in my spine. I also suffer from constant chronic pain in my lower back and neck. Went to doctors, neurologists, had neck and back fusion and take a handful of different meds for pain and sleep.

I have found that bubba kush, bullrider, grape ape work well for smoking to help with the seizures. I have also found that concentrates and strong edibles have a long lasting effect on seizures.

After 4-5 years I am still looking for answers in cannabis. I know that I would not be able to function without it. I know that cannabis helps with the side effects of the pills I take ( oxycontin, trazadone, diazapam ).

Good luck with your search in finding relief. As HappaGuy said you should check with a doctor and find out what is really going on.

respectfully

j

[Absynthe]

Oh, I go to a doctor every month, or twice a month now, for 5 years. Been to Neurologists, Orthopedic Surgeons, etc. Two sets of MRIs, almost entire spine.

No one wants to deal with me...I don't fit into a perfect pigeon hole. I do have long term neck and spinal issues from my accident, with 5 discs in my neck degenerating, and 3 in my lumbar, in addition to everything else. My migraines come out of the spinal injury and initial brain injury.

I did learn its okay to request the dance clubs to change the rate of the Mirrorballs, before I get near it. Faster doesn't phase me at all.

[lifeboy]

I also have epilepsy as well as other neurological and movement disorders.

I know that a varieties genetic phenotype isn't the only factor in what the CBN level of your flower is going to be. A lot of that cannabinoid profile is a result of when the grower decides to harvest the plants and if the plants are properly flushed upon harvest. When you let the trichomes on a mature plant develop longer, their color changes from clear to cloudy. The more you let the trichomes mature the higher the THC level becomes, but also, the CBN levels rise as well (and other molecules that breakdown THC) so some people like to harvest before the trichomes turn cloudy. The cannabinoid profile is even changing during the curing process. I think CBN increases as it cures, I'm not positive. I forgot where I read that so I can't double check.

I prefer bud that have trichomes on the cloudier side. The high come on smoother, peak more evenly, and last longer. I also find it's more full bodied and fulfilling. When I medicate with early harvested flower the high is more intense in the beginning but it wears fast into a kind of half medicated feeling. I don't like high to hit hard, especially when it's from a hard hitting sativa leaning hybrid, such as O.G. Kush. Some research says CBN doesn't effect the psychoactive effects of cannabis at all, so when judging whether CBN is effective one has to pay attention to their body and try to access whether it is helping.

I really don't know yet for myself. I just know I like organically grown indica flower that's harvested at just the right time. I like some Sativas with a strong indica backbone. Whether I smoke indica or sativa depends on what I'm doing, how I'm feeling and what time of day it is. If I feel like I'm going to have a seizure or am recovering from one, I head straight for the indicas. I like sativas for day medicating. It helps me keep relaxed, focused, and energized and keeps my seizures and tremors to a minimum.

Thanks to everyone who posted here. Good info. Much Love!

Peace,
Lifeboy

[HappaGuy]

I like Kushes a lot, but for about half a gram, after which it seems tolerance sets in.

But for that half gram it really does the trick.
--

Cloudy trichomes?! Ahh! Yeah, I think that's the nub. That sounds right. For sure I've had bud rich in clear trichomes that proved disappointing. Gonna test that out.

Nice clue lifeboy. Thx.

--

BTW since my previous posts Morpheus has larn't me about limonene and themsuch in our bud.

So now it appears to me that

• non-cannabinoid molecules such as limonene are necessary along with THC and other cannabinoids to produce the characteristic effects of MMJ,
  
• and that the ratio of these non-cannabinoids to cannabinoids, along with the ratio of cannabinoids to one another, is responsible for the characteristic effects of different genetic strains of MJ.

Thus in evaluating the effectiveness of MMJ strains for seizure disorder, the relevant factors in the profile seem to include relative quantities of

1. THC,
2. other cannabinoids, and
3. limonene and other non-cannabinoids.

There should be particular profiles of these factors that are optimal for reducing particular species of seizure activity.

It should be possible to isolate these factors into standardized strains and/or preparations that will be significantly more effective than anything available today.

Note that GW Pharmaceuticals in the UK is marketing Sativex, which is touted as a cannabis preparation delivered sublinguallly in standardized doses, without the "high".

That strikes me as evil, somehow, like taking song from an angel to make it fly more.

But we're talking medicine here. The spiritual aspect is secondary to identifying the necessary and sufficient set of factors that will reliably provide relief.

Anyway that's my current working hypothesis. I beg new information/correction.