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referee4 · 08-09-2009, 10:05 PM

It is believed that consuming Cimetidine an hour before smoking Cannabis, would potentate the Cannabis's effects.

It is believed because Cimetidine inhibits the CYP-450 enzyme, and metabolism mainly occurs in the liver by cytochrome P450 enzymes CYP2C9, CYP2C19, and CYP3A4.

Due to the inhibition of the CYP-450 enzyme, THC, the psychoactive substance in Cannabis, would not be able to be metabolized until the inhibition of the CYP-450 enzyme is lifted, which may take hours, thus increasing the duration of its effect.

This is a serious medication warning.

Stoners exempt

referee4 · 08-10-2009, 08:18 AM

This includes many many other anti acid products that are prescribed or OTC. if it contains Cimetidine . It has the potential.

referee4 · 09-25-2009, 04:17 PM

Update .. the effects are not as much as was previously reported

SpirituallyEnlightened · 09-26-2009, 01:01 PM

lmao.....

08-09-2009, 10:05 PM	#1 (permalink)
referee4 Fighting for the RIGHT to medicate In Peace. Join Date: Apr 2008 Co-Op: no Vendor: no Patient: yes Posts: 720 Rep Power: 68155	Cimetidine (Zantac) and MMJ It is believed that consuming Cimetidine an hour before smoking Cannabis, would potentate the Cannabis's effects. It is believed because Cimetidine inhibits the CYP-450 enzyme, and metabolism mainly occurs in the liver by cytochrome P450 enzymes CYP2C9, CYP2C19, and CYP3A4. Due to the inhibition of the CYP-450 enzyme, THC, the psychoactive substance in Cannabis, would not be able to be metabolized until the inhibition of the CYP-450 enzyme is lifted, which may take hours, thus increasing the duration of its effect. This is a serious medication warning. Stoners exempt Last edited by referee4; 08-09-2009 at 10:19 PM.. Reason: Medical advice

08-10-2009, 08:18 AM	#2 (permalink)
referee4 Fighting for the RIGHT to medicate In Peace. Join Date: Apr 2008 Co-Op: no Vendor: no Patient: yes Posts: 720 Rep Power: 68155	Re: Cimetidine (Zantac) and MMJ This includes many many other anti acid products that are prescribed or OTC. if it contains Cimetidine . It has the potential.

09-25-2009, 04:17 PM	#3 (permalink)
referee4 Fighting for the RIGHT to medicate In Peace. Join Date: Apr 2008 Co-Op: no Vendor: no Patient: yes Posts: 720 Rep Power: 68155	Re: Cimetidine (Zantac) and MMJ Update .. the effects are not as much as was previously reported

09-26-2009, 01:01 PM	#4 (permalink)
SpirituallyEnlightened WT Advanced Member Join Date: Jun 2008 Co-Op: no Vendor: no Patient: yes Posts: 723 Rep Power: 4417	Re: Cimetidine (Zantac) and MMJ lmao.....

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